CD3G

CD3G is a gene that encodes a subunit of the T cell receptor (TCR) complex. This complex plays a crucial role in the adaptive immune system by recognizing and binding to antigens presented by other cells. The protein product of CD3G is a transmembrane protein that associates with other CD3 subunits, namely CD3D, CD3E, and CD3Z, as well as the TCR alpha and beta chains. Together, these components form the complete TCR complex.

The CD3 complex is essential for T cell activation. Upon antigen binding by the TCR, the CD3 subunits transmit intracellular signals that lead to T cell proliferation, differentiation, and effector function. CD3G, in particular, contributes to the structural integrity and signaling capacity of the complex. Mutations or deficiencies in CD3G can impair T cell development and function, leading to severe immunodeficiency. Research into CD3G and its role in T cell signaling continues to provide insights into immune responses and potential therapeutic targets for various immune-related disorders.