CD32b
CD32B, also known as Fc gamma receptor IIb (FCGR2B), is a receptor in the Fc gamma receptor family that binds the Fc region of IgG antibodies. The FCGR2B gene encodes this receptor and is part of the FCGR gene cluster on chromosome 1. The receptor is expressed on B cells and certain myeloid cells.
It is a transmembrane protein with an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail,
Clinical and research relevance is tied to its role in modulating humoral immune responses. Variants in FCGR2B