CCL26targeted
CCL26, also known as eotaxin-3, is a chemokine of the CC chemokine family involved in the recruitment of eosinophils to sites of inflammation. It is produced by epithelial cells, fibroblasts, and other cell types in response to inflammatory signals and can be upregulated in allergic and type 2 inflammatory conditions. CCL26 exerts its effects primarily through binding to the CCR3 receptor on eosinophils and basophils, promoting chemotaxis and activation.
CCL26-targeted approaches refer to strategies designed to inhibit or neutralize the activity of CCL26 with the
Research avenues for CCL26-targeted therapy include neutralizing antibodies against CCL26, CCR3 receptor antagonists to block downstream
Challenges for CCL26-targeted strategies include chemokine system redundancy, potential off-target effects due to CCR3 expression on