CAPZA1CAPZA3

CAPZA1CAPZA3 refers to a pair of closely related genes, CAPZA1 and CAPZA3, that encode proteins involved in the regulation of actin filament dynamics. These proteins are part of the capping protein family. Capping proteins are essential for controlling the length and stability of actin filaments, which are crucial components of the cell's cytoskeleton. Actin filaments play vital roles in cell structure, cell movement, and intracellular transport.

CAPZA1, also known as capping protein (actin filament) regulator 1, and CAPZA3, also known as capping protein (actin filament) regulator 3, share significant sequence homology and functional similarities. They function by binding to the barbed (plus) ends of actin filaments, thereby preventing the addition of new actin monomers. This capping activity regulates the rate of actin polymerization and depolymerization, influencing the overall organization and dynamics of the actin cytoskeleton.

The precise roles of CAPZA1 and CAPZA3 in cellular processes are still being investigated, but their involvement has been implicated in various physiological and pathological conditions. Studies suggest that alterations in the expression or function of these capping proteins may contribute to diseases such as cancer and neurodegenerative disorders. Research continues to explore their specific contributions to cell migration, cell division, and tissue development.