Benzylpiperidine

Benzylpiperidine, commonly named 1-benzylpiperidine or N-benzylpiperidine, is an organic compound that consists of a piperidine ring bearing a benzyl substituent on the nitrogen atom. It is a tertiary amine and a simple example of N-alkylpiperidines. Its molecular formula is C12H17N and its approximate molecular weight is 175.3 g/mol.

Preparation and structure: It can be prepared by nucleophilic N-alkylation of piperidine with benzyl halides (for example benzyl bromide) in the presence of a base. The reaction installs the benzyl group on nitrogen, yielding the N-benzylpiperidine compound.

Uses: In chemistry, benzylpiperidine is commonly employed as an intermediate or building block in the synthesis of more complex piperidine-containing molecules, including pharmaceuticals and research compounds. It is not typically used as a pharmacologically active drug on its own.

Safety and regulation: Like many amines, benzylpiperidine should be handled with appropriate precautions to avoid skin contact and inhalation. It may be irritating to skin, eyes, and the respiratory tract. Depending on the jurisdiction, N-benzylpiperidine and related piperidine derivatives can be subject to regulation as chemicals or precursors used in the manufacture of controlled substances; consult local regulations.