BRGFs
BRGFs, or Brain-Derived Neurotrophic Factor Receptor Fragments, are a group of peptides derived from the proteolytic cleavage of the full-length Brain-Derived Neurotrophic Factor Receptor (TrkB). TrkB is a receptor tyrosine kinase that plays a crucial role in neuronal survival, growth, and synaptic plasticity, primarily through the action of its ligand, BDNF.
BRGFs can be generated in various cellular contexts and under different physiological and pathological conditions. Their
Research into BRGFs suggests they can have diverse effects on neuronal function. Some BRGFs may act as