BRCA2n

BRCA2n is a variant of the BRCA2 gene, which is located on chromosome 13. The BRCA2 gene is responsible for producing a protein that plays a crucial role in DNA repair and genome stability. Mutations in the BRCA2 gene are associated with an increased risk of developing breast and ovarian cancer, as well as other types of cancer such as prostate, pancreatic, and colorectal cancer. BRCA2n, specifically, refers to a non-coding variant of the BRCA2 gene, which does not alter the protein's structure or function. The significance of BRCA2n variants is still a subject of ongoing research, but they are generally considered to have a lower risk of cancer compared to coding mutations in the BRCA2 gene. However, it is important to note that the impact of BRCA2n variants on cancer risk can vary among individuals, and further studies are needed to fully understand their implications. Genetic counseling and testing are recommended for individuals with a family history of breast or ovarian cancer to determine their personal risk and make informed decisions about preventive measures and screening options.