BIG2

BIG2, also known as Bromodomain-containing protein 2, is a human gene that encodes a protein belonging to the bromodomain family. These proteins are characterized by a conserved domain that binds to acetylated lysine residues, a modification often found on histone proteins. This interaction allows bromodomain proteins to act as epigenetic readers, recognizing and interpreting the histone code to regulate gene expression.

The BIG2 protein itself plays a role in various cellular processes, including transcriptional regulation and chromatin remodeling. It is thought to be involved in the assembly of multiprotein complexes that modulate gene transcription. Research has suggested potential involvement of BIG2 in processes such as cell proliferation, differentiation, and development. While its precise functions are still under investigation, BIG2 is considered an important component of the cellular machinery that controls gene activity. Dysregulation of BIG2 has been implicated in certain disease states, prompting ongoing research into its therapeutic potential.