BAG2

BAG2, also known as BAG cochaperone 2, is a protein that functions as a cochaperone for heat shock proteins, particularly Hsp70. It is a member of the BAG domain family, characterized by a conserved BAG domain at its C-terminus. This domain is crucial for its interaction with Hsp70 and other chaperone proteins. BAG2 plays a role in protein folding, refolding of misfolded proteins, and protein degradation pathways. It can modulate the ATPase activity of Hsp70, influencing its ability to bind and release substrate proteins. The protein is found in various tissues and is implicated in cellular processes such as cell cycle regulation, apoptosis, and the stress response. Dysregulation of BAG2 has been observed in several diseases, including cancer and neurodegenerative disorders, suggesting its involvement in disease pathogenesis. Further research is ongoing to fully elucidate its complex functions and therapeutic potential.