Astrozytenendfüße

Astrozytenendfüße, also known as astrocytic end-feet or pedicels, are specialized terminal expansions of astrocytes. These star-shaped glial cells play a crucial role in the central nervous system. Astrozytenendfüße are particularly important as they form a major component of the blood-brain barrier. They cover the outer surface of capillaries in the brain, creating a physical and metabolic barrier that regulates the passage of substances from the blood into the brain tissue. This selective permeability is essential for maintaining a stable and protected environment for neurons. Beyond their role in the blood-brain barrier, astrozytenendfüße are also involved in synaptic function. They ensheath synapses, the junctions between neurons, and can influence neurotransmission by taking up and releasing neurotransmitters and ions. This interaction helps to regulate synaptic strength and plasticity. Furthermore, they contribute to the structural support of the central nervous system and play a role in nutrient and waste exchange between blood vessels and neurons. Their close association with blood vessels and neuronal synapses highlights their vital, multifaceted function within the brain.