AntiC5Moleküle

AntiC5Moleküle, also known as anti-C5 antibodies or complement C5 inhibitors, are a class of therapeutic agents that target the complement system, a crucial part of the innate immune system. Specifically, they bind to and inhibit the function of the complement protein C5. The complement system is a cascade of proteins that plays a role in inflammation, opsonization, and cell lysis. Activation of the complement cascade can lead to the formation of the membrane attack complex (MAC), which can damage cells. C5 is a key protein in this cascade, as its cleavage by C5 convertase initiates the formation of MAC. By inhibiting C5, AntiC5Moleküle prevent the generation of MAC and downstream inflammatory responses. This mechanism of action makes them valuable in treating a variety of autoimmune and inflammatory diseases where excessive complement activation contributes to tissue damage. Examples of such conditions include paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and certain types of glomerulonephritis. The development of AntiC5Moleküle has offered new therapeutic options for patients with these debilitating conditions, aiming to reduce disease activity and improve patient outcomes by selectively modulating the complement cascade.