Aminoglykosidid

Aminoglycosidid is a family of polyamines that contain an amino group and a sugar moiety. These compounds are typically produced by bacteria, where they play a role in the process of DNA repair and are involved in the modulation of membrane electrical potential.

Aminoglycosidid antibiotics are a class of antibiotics that have been derived from aminoglycosidid compounds found in the bacterium Streptomyces finveculi. These antibiotics work by binding to the bacterial ribosome and inhibiting protein synthesis, leading to cell death.

Aminoglycosidid antibiotics are typically administered intravenously or intramuscularly, and their activity is broad, affecting a wide range of Gram-negative and some Gram-positive bacteria. They are effective against various types of bacterial infections, including severe and life-threatening conditions such as sepsis, meningitis, and endocarditis.

However, aminoglycosidid antibiotics can have significant side effects due to their potential for ototoxicity and neurotoxicity. These effects may include hearing loss, damage to the vestibular apparatus, and kidney damage.

Due to the risk of resistance development and the availability of safer alternatives, the use of aminoglycosidid antibiotics has been declining in recent years. These medications are typically reserved for specific cases where alternative treatments are not feasible or have proven ineffective.

In summary, aminoglycosidid represents a class of compounds with a wide range of biological activities, including their role as a precursor in the production of certain antibiotics, as well as their own direct action as antimicrobial agents.