Alpha1microglobulin

Alpha-1-microglobulin (A1M) is a small protein found in the blood and other bodily fluids. It is produced by the liver and plays a crucial role in the immune system. A1M binds to various proteins, including immunoglobulins, and helps to degrade them, thereby regulating the immune response. This process is particularly important for the clearance of immune complexes, which are aggregates of antibodies and antigens.

A1M is also involved in the regulation of complement activation, a key component of the innate immune system. It can inhibit the classical pathway of complement activation, which helps to prevent excessive inflammation and tissue damage.

Elevated levels of A1M in the blood can be indicative of certain medical conditions, such as liver disease, chronic kidney disease, and certain types of cancer. Conversely, low levels of A1M may be associated with conditions that affect the immune system, such as autoimmune disorders.

A1M is typically measured in blood tests to monitor liver function and to assess the risk of certain diseases. It is also used as a marker in clinical trials and research studies to evaluate the efficacy of treatments and interventions.