ALKBH8

ALKBH8, also known as AlkB homolog 8, is a protein encoded by the ALKBH8 gene in humans. This gene is part of the AlkB family of enzymes, which are known for their role in DNA repair. Specifically, ALKBH8 functions as a dioxygenase. It is involved in the repair of oxidative damage to DNA, particularly the removal of methyl groups from guanine bases. This process is crucial for maintaining genomic stability and preventing mutations that can lead to diseases like cancer.

The enzyme ALKBH8 plays a critical role in cellular defense against reactive oxygen species. In addition to its DNA repair function, ALKBH8 has also been implicated in RNA modification. It is known to demethylate specific bases within transfer RNA (tRNA) molecules. This modification is important for proper tRNA structure and function, which in turn affects protein synthesis. Dysregulation of ALKBH8 has been linked to various cellular processes, including cell cycle progression and apoptosis. Research is ongoing to fully elucidate the diverse functions of ALKBH8 and its potential involvement in disease pathogenesis.