ACSS2

ACSS2, also known as acetyl-CoA synthetase 2, is an enzyme that plays a crucial role in cellular metabolism. It is encoded by the ACSS2 gene. This enzyme is primarily involved in the synthesis of acetyl-CoA from acetate, a process that can occur independently of glucose metabolism. Acetyl-CoA is a vital molecule that serves as a central hub in cellular energy production and biosynthesis pathways.

The ACSS2 enzyme catalyzes the reaction where acetate is converted to acetyl-CoA using ATP. This pathway is particularly important in certain physiological conditions, such as fasting or when acetate is readily available from the diet or other metabolic processes. Acetyl-CoA produced by ACSS2 can then enter the citric acid cycle for energy generation or be used in the synthesis of fatty acids and cholesterol.

Recent research has highlighted the involvement of ACSS2 in various cellular processes beyond basic metabolism. It has been implicated in regulating gene expression and influencing epigenetic modifications. Furthermore, dysregulation of ACSS2 activity has been linked to certain diseases, including cancer, where its role in fueling tumor growth and survival is being actively investigated. Understanding the precise functions and regulation of ACSS2 is an ongoing area of scientific inquiry with potential implications for therapeutic interventions.