4methylumbelliferylDglucuronide

4-Methylumbelliferone, often abbreviated as 4-MU, is a naturally occurring organic compound belonging to the coumarin family. It is found in various plants, including Angelica archangelica (angelica), and is also synthesized industrially. Its chemical structure consists of a benzopyrone nucleus with a methyl group at the 4-position and a hydroxyl group at the 7-position.

One of the most notable properties of 4-MU is its fluorescence. Under ultraviolet light, it emits a bright blue fluorescence, which makes it useful as a fluorescent indicator and probe in various scientific applications. This fluorescence is pH-dependent, increasing as the pH rises.

In addition to its fluorescent properties, 4-MU has garnered attention for its potential biological activities. Research has explored its use in inhibiting hyaluronan synthesis, an important component of connective tissues. This has led to investigations into its therapeutic potential for conditions where excessive hyaluronan is implicated, such as osteoarthritis and certain types of cancer. It is also used in some cosmetic products as a sunscreen agent due to its ability to absorb UV radiation. Furthermore, 4-MU is employed in analytical chemistry for detecting enzyme activity and as a component in some food flavorings.