4chlorobenzoic

4-chlorobenzoic acid is an organic compound with the molecular formula C7H5ClO2. It is a colorless to white crystalline solid and is highly soluble in water.

Chemical Properties

The compound has a faint acetic odor and is slightly acidic. It is known to form ester derivatives through chemical reactions with alcohols.

Manufacturing and Uses

The synthesis of 4-chlorobenzoic acid can be achieved via the ethoxy carbonylation of chlorobenzene in the presence of a copper catalyst. Another common method involves the oxidation of 4-chlorotoluene. 4-chlorobenzoic acid is an important intermediate in organic synthesis and is used in various chemical reactions.

Applications

In biochemical research, 4-chlorobenzoic acid is used as a specific inhibitor of the gut enzyme choloylglycine hydrolase. Additionally, it has been reported to have antifungal activity. It can also be employed as a substrate in standard and photoreceptor-based assays. Furthermore, it forms chelates and can act as a nucleophilic reagent, participating in chemical reactions.

Potential Toxicity

Exposure to 4-chlorobenzoic acid can result in skin irritation and eczema in some individuals. It is also considered a toxic intermediate in chemical synthesis processes.

Handling and Storage

The compound should be manipulated and stored under strict safety guidelines due to its acidic properties and potential toxicity.