22q122

22q122 is not a standard or widely used cytogenetic designation in human genetics. Chromosome 22 locations are described using the long-arm notation “q” and band designations such as 22q11.2 or 22q12.1. A term like 22q122 may reflect a typographical error, a study-specific shorthand, or an informal reference to a locus within the 22q12 region. Without precise coordinates, it is not possible to assign specific genes, functions, or disease associations to 22q122.

Genomic context: If a reference points to a locus within 22q12, the exact gene content depends on the defined interval. Researchers and clinicians typically use precise cytogenetic bands or base-pair coordinates when describing locations. Variants in such regions can include copy-number changes, single-nucleotide variants, or structural rearrangements, detectable by methods such as microarray comparative genomic hybridization, sequencing, or fluorescence in situ hybridization.

Clinical relevance: The best-known clinically significant locus on chromosome 22 is 22q11.2, associated with deletion syndrome and related conditions; 22q12 has been studied for various associations but is not tied to a single widely recognized syndrome. Any clinical interpretation of a putative 22q122 finding requires validated coordinates and correlation with testing reports and clinical features.

See also: Chromosome 22; 22q11.2 deletion syndrome; cytogenetic nomenclature; genomic coordinates.