17p131

17p131 is not a standard or widely accepted cytogenetic band designation in human chromosome nomenclature. Human chromosome 17 short arm (p) is divided into a series of bands such as p11.2, p13.1, p13.3, and so on, with 17p13.1 and 17p13.3 being commonly encountered in the literature. A notation like “17p131” is typically a typographical error or an informal shorthand for a more precise band designation (for example, 17p13.1 or 17p13.3). When precise band designation is needed for clinical or research purposes, the exact coordinates or a clearly stated band are used to define the genomic interval and its gene content.

If the intended region is 17p13.1, it lies on the proximal part of the short arm of chromosome 17 and contains multiple genes. The clinical significance of rearrangements in this region depends on the exact coordinates and whether there is a deletion, duplication, or translocation. The better-characterized bands in that vicinity include 17p13.3, where deletions can cause Miller-Dieker syndrome (LIS1/PAFAH1B1 and other gene deletions) and where duplications or other rearrangements have been described in neurodevelopmental disorders. Another well-known interval on 17p is 17p11.2, where deletions or duplications give rise to Smith-Magenis syndrome or Potocki-Lupski syndrome, respectively.

In summary, 17p131 likely reflects a mistaken notation; precise band designation should be clarified to assess genomic content and clinical relevance. See also 17p13.3, 17p11.2, and related bands on chromosome 17.