16p132

16p132 is a chromosomal designation that typically would refer to a locus on the short arm (p) of chromosome 16, near region 13.2. However, the form “16p132” is nonstandard in official cytogenetic nomenclature, where the decimal separator is used (for example, 16p13.2). The string 16p132 may reflect a typographical variant, an informal shorthand used in some datasets, or a misinterpretation of 16p13.2. When encountering this label, it is important to verify the exact coordinates against authoritative genome builds and ISCN-style reports to determine the intended region.

Genomic context

The short arm of chromosome 16 contains multiple bands, including those in the 16p13 region. The precise gene content of any 16p13.2-like region can vary among individuals due to structural variation. Copy-number variations (CNVs) in this region have been observed in population studies and clinical cohorts, and their boundaries can differ between detected CNVs. The region is generally considered gene-rich, and the presence of a CNV can influence dosage of multiple genes, with potential phenotypic consequences that depend on size, gene content, and inheritance.

Clinical interpretation

In clinical testing, a CNV spanning a 16p13.2-like region would be interpreted by considering CNV size, the specific genes involved, zygosity, inheritance, and the patient’s phenotype. Many CNVs in this area are classified as variants of uncertain significance, while larger deletions or duplications affecting dosage-sensitive genes can be associated with neurodevelopmental features, congenital anomalies, or other traits. Definitive conclusions require corroborating data from family studies and public variant databases.

See also

Chromosome 16, cytogenetic nomenclature, copy-number variation, ISCN, DECIPHER, ClinGen.