12p133

12p133 is a cytogenetic designation referring to a locus on the short arm (p) of human chromosome 12. In standard human genome notation, the more common form is 12p13.3, which identifies a discrete band defined by G-banding on the chromosome's short arm. The 12p13.3 region maps to a specific interval in genome assemblies such as GRCh38 and GRCh37; exact base-pair coordinates depend on the reference build.

Genomic content and organization: The region contains multiple annotated features, including protein-coding genes, non-coding RNAs, and regulatory elements. The gene content is defined by genome annotation tracks in resources like Ensembl and RefSeq, and may vary with assembly updates. As a cytogenetic band, 12p13.3 is used in reporting structural variation and chromosomal abnormalities.

Clinical and research significance: Structural variations—such as deletions and duplications—envolving 12p13.3 have been reported in various clinical contexts, but robust associations with specific disorders typically involve larger intervals that extend beyond a single band. The region is also examined in cytogenetic testing, fluorescence in situ hybridization (FISH), and CNV studies.

Note: 12p133 appears to be a variant spelling of 12p13.3; if a different locus or nomenclature is intended, please specify.

See also: Chromosome 12, cytogenetic bands, 12p13.3, copy number variation.