virRB

virRB is a variable region of the immunoglobulin kappa locus in the human genome. This specific region is located on chromosome 2 and plays a significant role in the development of B cells and the generation of antibody diversity. The immunoglobulin kappa locus contains several variable gene segments (V genes) that rearrange during B cell maturation through a process called V(D)J recombination. These V genes are responsible for encoding the variable regions of the kappa light chains of antibodies. The virRB region encompasses a particular set of these V kappa genes, and their specific arrangement and sequence contribute to the repertoire of antibodies an individual can produce. Understanding the virRB region is important for research into immunology, autoimmune diseases, and B cell malignancies, as alterations or mutations within this locus can have implications for immune function and disease susceptibility. Genetic studies of virRB have helped map the human immunoglobulin kappa locus and provided insights into the mechanisms of immune system development and diversity.