verenkantasolujoukko

Verenkantasolujoukko, also known as the peripheral blood mononuclear cell (PBMC) fraction, is a component of whole blood that is commonly used in various medical and research applications. It is isolated from the peripheral blood of individuals and consists primarily of white blood cells, including lymphocytes, monocytes, and granulocytes. The PBMC fraction is obtained through a process called leukapheresis, where whole blood is separated into its constituent components using a centrifuge.

The PBMC fraction is valuable in research and clinical settings due to its rich content of immune cells. It is used in studies of immune function, disease mechanisms, and the development of immunotherapies. In clinical practice, PBMCs are employed in the preparation of cellular therapies, such as adoptive cell transfer, where immune cells are isolated from a patient's blood and modified or expanded in the laboratory before being reinfused to treat specific diseases, such as cancer.

The isolation of PBMCs involves several steps, including the collection of whole blood, the removal of red blood cells, and the separation of the remaining white blood cells. The resulting PBMC fraction is typically used fresh or frozen for subsequent analysis or therapeutic applications. The quality and purity of the PBMC fraction are critical for its successful use in research and clinical settings, and various techniques are employed to ensure the isolation of a high-quality PBMC fraction.