tiotepa
Tiotepa, commonly known as thiotepa, is a synthetic cytotoxic chemotherapy agent used to treat various cancers. It is a bifunctional alkylating agent of the phosphoramide mustard family. By alkylating DNA, thiotepa creates cross-links between DNA strands, inhibiting replication and transcription and leading to cell death. Some cross-linking of RNA may also contribute to its cytotoxic effects.
Indications and administration: Thiotepa is used systemically for certain solid tumors and hematologic malignancies, and intravesically
Pharmacokinetics and interactions: Thiotepa is rapidly distributed and largely eliminated by the kidneys, with hepatic metabolism
Adverse effects and safety: The principal dose-limiting toxicity is myelosuppression, with neutropenia and thrombocytopenia. Other frequent
History and status: Thiotepa has been in clinical use since the mid-20th century and remains an option