tTreg

tTreg, short for regulatory T cells, are a subset of T cells that play a crucial role in maintaining immune homeostasis and preventing autoimmunity. They are characterized by the expression of the transcription factor Foxp3, which is essential for their development and function. tTreg cells are derived from CD4+ T cells in the thymus and are further differentiated in the periphery. They exert their regulatory functions through the production of immunosuppressive cytokines, such as IL-10 and TGF-β, and by directly inhibiting the activation and proliferation of other immune cells. tTreg cells are involved in various immune responses, including the regulation of inflammation, the prevention of autoimmunity, and the maintenance of tolerance to self-antigens. They are also implicated in the pathogenesis of certain autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where their dysfunction or depletion can contribute to disease progression. The study of tTreg cells has provided valuable insights into the mechanisms of immune regulation and has opened up new avenues for the development of therapeutic strategies for immune-mediated disorders.