serine195
Serine195 (Ser195) is the serine residue numbered 195 in the catalytic center of many serine proteases within the chymotrypsin family. This numbering, based on chymotrypsin, is a standard reference in describing the active-site architecture of related enzymes, including trypsin and other endopeptidases.
In serine proteases, Ser195 is part of the catalytic triad that also includes His57 and Asp102. The
The catalytic cycle proceeds with formation of the acyl-enzyme intermediate, followed by deacylation where a water
Mutations at Ser195 typically disrupt protease activity, underscoring its essential role in catalysis. Ser195 remains a