salvarsan
Salvarsan, also known as arsphenamine or by its trade name Salvarsan, was the first systemic antimicrobial agent used to treat syphilis. It is an organoarsenic compound discovered as part of Paul Ehrlich's search for a "magic bullet" and introduced with Sahachiro Hata in 1909–1910. The compound, later referred to as the 606th in Ehrlich's series, demonstrated activity against Treponema pallidum, the bacterium that causes syphilis, and became the standard therapy for several decades.
Chemically, arsphenamine is an arsenic-containing organic compound. Its therapeutic effect is thought to arise from interference
Administration of Salvarsan was by deep intramuscular injection in hospital settings. Treatment regimens typically spanned weeks
Legacy: Salvarsan represented a major milestone in antimicrobial therapy. It remained the standard systemic therapy for