pseudokinázok

Pseudokinases are a group of proteins that share structural and functional similarities with true kinases, but lack the ability to catalyze the transfer of phosphate groups. They are often found in various biological processes, including signal transduction, cell cycle regulation, and DNA repair. Pseudokinases are characterized by their conserved kinase-like domains, which include the catalytic loop and the ATP-binding pocket, but lack the catalytic residues necessary for phosphorylation.

The term "pseudokinase" was first introduced in the late 1990s to describe proteins that were initially thought to be kinases but lacked the ability to phosphorylate substrates. Since then, numerous pseudokinases have been identified and characterized, with many playing crucial roles in cellular processes. Some pseudokinases are involved in protein-protein interactions, while others are involved in the regulation of gene expression.

Pseudokinases are typically classified based on their structural and functional similarities to true kinases. For example, the pseudokinase family includes proteins with conserved kinase-like domains, such as the pseudokinase domain (PKD) and the pseudokinase-like domain (PKLD). These domains are often found in proteins that are involved in signal transduction and cell cycle regulation.

In summary, pseudokinases are a diverse group of proteins that share structural and functional similarities with true kinases but lack the ability to catalyze the transfer of phosphate groups. They play crucial roles in various biological processes and are often involved in protein-protein interactions and the regulation of gene expression.