otofarmakologi

Otofarmakologi is the branch of pharmacology that specifically studies the effects of drugs on the ear and hearing. It explores how medications can influence the structures and functions of the auditory system, including the outer, middle, and inner ear. This field investigates both therapeutic and adverse effects of drugs on hearing, balance, and the overall health of the ear.

The primary goals of otofarmakology include developing new treatments for hearing loss, tinnitus, vertigo, and other ear-related disorders. It also focuses on understanding the mechanisms by which certain medications can cause ototoxicity, or damage to the ear, which can lead to permanent hearing impairment or balance problems. Common ototoxic agents include certain antibiotics, chemotherapy drugs, and aspirin.

Research in otofarmakology involves preclinical studies using animal models and in vitro systems, as well as clinical trials in humans. It examines drug delivery methods to the ear, such as topical ear drops or systemic administration, and their subsequent absorption, distribution, metabolism, and excretion within the auditory system. The ultimate aim is to optimize the use of pharmacological agents for ear health while minimizing potential risks.