osteoklák

Osteoklast is a type of bone cell that is responsible for bone resorption, the process of breaking down bone tissue. These cells are multinucleated, meaning they contain multiple nuclei, and originate from hematopoietic stem cells in the bone marrow. Osteoclasts are crucial for maintaining bone health by removing old or damaged bone tissue and releasing minerals like calcium and phosphate into the bloodstream. This process is tightly regulated and balanced by bone-building cells called osteoblasts.

The activity of osteoclasts is influenced by various hormones and signaling molecules, including parathyroid hormone and calcitonin. Dysregulation of osteoclast function can lead to bone diseases such as osteoporosis, where bone mass decreases, making bones more prone to fractures. Conversely, excessive osteoclast activity can contribute to conditions like Paget's disease of bone. The intricate interplay between osteoclasts and osteoblasts is essential for bone remodeling, a continuous process that occurs throughout life, ensuring the integrity and strength of the skeleton. Understanding osteoclast biology is vital for developing treatments for bone disorders.