osteoclasterna
Osteoclasts are large multinucleated cells responsible for bone resorption, a vital process in bone remodeling. They originate from hematopoietic stem cells of the monocyte-macrophage lineage. During their differentiation, these precursor cells fuse together, forming the characteristic multinucleated structure of mature osteoclasts. These cells play a crucial role in maintaining bone health by breaking down old or damaged bone tissue.
The process of bone resorption involves osteoclasts attaching to the bone surface and creating a sealed microenvironment.
Osteoclast activity is tightly regulated by various signaling pathways and hormones. For instance, parathyroid hormone (PTH)