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Nitrosative refers to processes and species related to nitroso groups or nitrogen monoxide derivatives. In chemistry, nitrosative processes include nitrosation, where a nitroso group (-NO) is introduced into substrates such as amines to form N-nitrosamines, and nitrosylation, the addition of nitric oxide (NO) to metal centers or thiol groups to form metal-NO complexes or S-nitrosothiols (RS-NO). Nitrosation can lead to stable N-nitroso compounds; nitrosylation is a key mechanism in signaling and enzyme regulation.
In biology, reactive nitrogen species (RNS) such as nitric oxide (NO), nitrogen dioxide (NO2), dinitrogen trioxide
Nitrosative stress describes conditions where excessive RNS formation overwhelms antioxidant defenses, causing modifications and damage, including
Measurement and study typically involve detecting nitrosothiols, nitrite/nitrate as RNS proxies, and protein nitration products. Distinguishing