nichtmegaloblastische

Nichtmegaloblastische refers to anemia that is not characterized by the abnormal cell size and nuclear-cytoplasmic asynchrony seen in megaloblastic anemia. This type of anemia is not caused by vitamin B12 or folate deficiency, which are the primary culprits behind megaloblastic anemia. Instead, nichtmegaloblastische anemias stem from a variety of other underlying causes. These can include chronic disease, iron deficiency, hemolysis (the premature destruction of red blood cells), and bone marrow disorders. The red blood cells in nichtmegaloblastische anemia are typically normocytic (normal in size) or microcytic (smaller than normal), and their nuclei appear normal. Diagnosis involves a complete blood count to assess red blood cell indices, followed by investigations to identify the specific underlying cause. Treatment is directed at the root cause of the anemia, such as iron supplementation for iron deficiency anemia, or addressing the chronic inflammatory process in anemia of chronic disease. The absence of megaloblastic changes in the bone marrow and peripheral blood is a key distinguishing feature.