nedreglera
Nedreglera is a Swedish verb meaning to downregulate or to reduce the regulatory intensity of something. The word combines ned-, meaning downward, with reglera, to regulate. In biology and biochemistry, nedreglera is used to describe downregulation: a decrease in receptor numbers or in signal-transduction activity in response to sustained stimulation. Mechanisms include receptor internalization, decreased gene expression, or degradation of signaling proteins.
In medical pharmacology, downregulation can contribute to tolerance to drugs: for example, chronic exposure to a
In regulatory policy, nedreglera may be used to describe actions that reduce regulatory burdens or ease requirements,
Related terms include downregulation, receptor desensitization, and avreglera (deregulation) in policy.