myeloperoksidaasit

Myeloperoxidase is an enzyme found in the azurophil granules of neutrophils, a type of white blood cell. It plays a crucial role in the immune response by catalyzing the production of hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride ions (Cl-). This reaction is part of the body's defense mechanism against bacterial infections. Hypochlorous acid is a potent antimicrobial agent that can kill or inactivate a wide range of microorganisms, including bacteria, viruses, and fungi. Myeloperoxidase is also involved in the regulation of inflammatory responses and the resolution of tissue damage. Its activity is tightly regulated to prevent excessive tissue damage and to ensure that the immune response is directed against pathogens rather than healthy tissues. Deficiencies or abnormalities in myeloperoxidase function have been linked to various diseases, including chronic granulomatous disease, a rare genetic disorder characterized by recurrent infections and impaired immune function.