membraneslaminins

Membraneslaminins, also known as lamins, are a family of intermediate filament proteins that play a crucial role in the structure and function of the nuclear envelope. They are composed of three main types: A, B, and C. Each type has distinct isoforms, which are encoded by different genes. Lamins A and C are primarily found in the inner nuclear membrane, while lamin B is located in the outer nuclear membrane. The lamins form a filamentous network that provides mechanical support and stability to the nuclear envelope. They also interact with various proteins and chromatin, influencing nuclear organization and function. Dysregulation of lamins has been linked to several diseases, including muscular dystrophies, progeria, and cancer. The study of lamins continues to be an active area of research, with ongoing efforts to understand their roles in nuclear dynamics and disease pathogenesis.