log10A1

Log10A1 is a gene located on the long arm of chromosome 11 at position 11q13. It encodes for the enzyme 10-formyltetrahydrofolate dehydrogenase, which is a key enzyme in the folate metabolic pathway. This enzyme catalyzes the oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide, playing a crucial role in the recycling of folate, a vitamin essential for DNA synthesis and repair.

Mutations in the Log10A1 gene have been associated with various clinical conditions, including megaloblastic anemia, a type of anemia characterized by large, immature red blood cells. This condition can lead to fatigue, weakness, and other symptoms due to the impaired production of red blood cells. Additionally, Log10A1 mutations have been linked to other neurological and developmental disorders, highlighting the gene's importance in both hematological and neurological systems.

The Log10A1 gene is highly conserved across species, suggesting its critical role in fundamental biological processes. Research into this gene continues to provide insights into the molecular mechanisms underlying folate metabolism and its implications for human health. Understanding the function and regulation of Log10A1 is essential for developing targeted therapies for conditions associated with mutations in this gene.