irinotekaanmetabolian
Irinotecan is a chemotherapy drug used to treat certain types of cancer, including colorectal cancer. It is a topoisomerase I inhibitor, which means it works by interfering with the function of an enzyme called topoisomerase I, which is involved in DNA replication and repair. This interference leads to the formation of DNA breaks, which can be lethal to cancer cells.
Irinotecan is administered intravenously and is typically given in combination with other chemotherapy drugs. The most
Irinotecan is metabolized in the liver by the enzyme CYP3A4, which is also responsible for the metabolism
The active metabolite of irinotecan, SN-38, is also metabolized by CYP3A4. This can lead to the formation
In summary, irinotecan is a chemotherapy drug used to treat certain types of cancer. It is metabolized