inflammasoomien
Inflammasomes are multiprotein intracellular sensing platforms that play a crucial role in innate immunity. They are primarily responsible for detecting a wide range of danger signals, including pathogen-associated molecular patterns (PAMPs) from microbes and damage-associated molecular patterns (DAMPs) released from stressed or injured host cells. Upon activation, inflammasomes assemble into a large complex that cleaves and activates key inflammatory mediators, most notably the inflammatory caspases.
The canonical inflammasome pathway involves the activation of caspase-1, which then processes pro-interleukin-1 beta (pro-IL-1β) and
The NLRP3 inflammasome is perhaps the most studied and is activated by a diverse array of stimuli,