homologsDLG1

HomologsDLG1 is a term used in genomic resources to designate the collection of homologous proteins to DLG1 (Discs large homolog 1) across diverse species. DLG1 encodes a membrane-associated guanylate kinase (MAGUK) scaffolding protein that participates in organizing signaling complexes at vertebrate postsynaptic densities and at epithelial junctions. The DLG1 protein typically contains multiple protein interaction domains, including PDZ, SH3, and a guanylate kinase–like (GUK) domain, which are largely conserved among metazoan homologs. The homologsDLG1 dataset or category includes vertebrate orthologs such as DLG1 in human, mouse, and rat; invertebrate orthologs such as Dlg in Drosophila and DLG-1 in C. elegans; as well as DLG family paralogs in various species.

Entries within homologsDLG1 are used to study evolutionary conservation of domain architecture, the functional diversification of MAGUK scaffolds, and the evolution of synaptic and cell junction signaling networks. Analysts typically perform multiple sequence alignments, domain mapping, and phylogenetic inference to distinguish orthology from paralogy and to infer ancestral sequences. Data sources commonly integrate curated protein sequences, gene models, and functional annotations from public databases such as Ensembl/Ensembl Compara, OrthoDB, and NCBI.

Limitations include potential heterogeneity in annotation quality across species and the challenge of distinguishing true functional conservation from convergent domain composition. See also DLG1, DLG family, and postsynaptic density proteins.