hairpinribozymeja
Hairpin ribozymes are small self-cleaving RNA motifs that catalyze site-specific RNA cleavage through a transesterification reaction. They occur naturally in viroids and viroid-like satellite RNAs, and are among the best studied self-cleaving ribozymes after the hammerhead ribozyme. Hairpin ribozymes typically comprise about 50 to 60 nucleotides and fold into a compact hairpin structure with two helical segments converging on a catalytic core.
The catalytic core is formed by conserved sequence and base-pairing interactions within the loops and stems,
In natural systems, hairpin ribozymes participate in processing of replication intermediates and regulation of RNA activity
Compared with other small self-cleaving ribozymes, the hairpin ribozyme has a distinct sequence and structural organization