glukuronat

Glucuronate is a uronic acid that is a component of many important biological molecules. It is derived from glucose, with the terminal carbon atom oxidized to a carboxylic acid group. Glucuronate is a key structural unit in glycosaminoglycans, which are long, unbranched polysaccharides found in connective tissues, the extracellular matrix, and cell surfaces. Examples of glycosaminoglycans containing glucuronate include hyaluronic acid, chondroitin sulfate, and heparin. These molecules play vital roles in lubrication, structural integrity, and cell signaling.

In addition to its presence in glycosaminoglycans, glucuronate is also involved in the process of glucuronidation. Glucuronidation is a metabolic pathway in which glucuronate is conjugated to various endogenous compounds, such as bilirubin and steroid hormones, as well as exogenous substances like drugs and toxins. This conjugation increases the water solubility of these substances, facilitating their excretion from the body, primarily through urine and bile. This detoxification mechanism is crucial for maintaining homeostasis and preventing the accumulation of potentially harmful compounds.