gastriniarvoon

Gastrin is a hormone produced by the stomach's G cells, primarily in response to the presence of food in the stomach. Its primary function is to stimulate the secretion of hydrochloric acid and enzymes by the stomach's parietal cells and chief cells, respectively. Gastrin also plays a role in the regulation of gastric motility and the growth of the stomach's mucosa.

The release of gastrin is stimulated by the presence of food in the stomach, as well as by certain drugs, such as histamine and acetylcholine. It is inhibited by the presence of acid in the stomach, as well as by certain drugs, such as somatostatin and secretin.

Gastrin is a polypeptide hormone consisting of 27 amino acids. It is synthesized as a larger precursor protein, progastrin, which is then cleaved to form gastrin. Gastrin is released from the G cells in response to the presence of food in the stomach, and it acts on the stomach's parietal cells and chief cells to stimulate the secretion of hydrochloric acid and enzymes.

Gastrin levels are elevated in conditions such as Zollinger-Ellison syndrome, a rare disorder characterized by the production of excessive amounts of gastrin, leading to the formation of multiple ulcers in the stomach and duodenum. Gastrin levels are also elevated in conditions such as atrophic gastritis and pernicious anemia, which are characterized by the atrophy of the stomach's mucosa.

Gastrin is also used as a diagnostic tool in the evaluation of gastric ulcers and other conditions that affect the stomach. Gastrin levels can be measured in the blood or in the gastric juice, and they are elevated in conditions such as Zollinger-Ellison syndrome and gastric ulcers. Gastrin levels are also used to monitor the response to treatment in conditions such as Zollinger-Ellison syndrome and gastric ulcers.