gammorelated

Gammaglobulin, also known as immunoglobulin, is a protein produced by plasma cells, a type of white blood cell. These proteins are responsible for identifying and neutralizing foreign substances such as bacteria and viruses. Gammaglobulin is a key component of the immune system.

There are five main classes of gammaglobulin: IgG, IgA, IgM, IgD, and IgE, each with distinct functions and locations within the body. IgG is the most abundant class and plays a crucial role in fighting infections. IgA is found in secretions like saliva and mucus, providing mucosal immunity. IgM is the first antibody produced during an immune response. IgD is found on the surface of B cells and plays a role in B cell activation. IgE is involved in allergic reactions and defense against parasites.

Intravenous immunoglobulin (IVIg) therapy uses pooled gammaglobulin from thousands of donors. It can be used to treat a variety of immune deficiencies and autoimmune disorders. IVIg works by modulating the immune system, suppressing harmful antibodies, and providing passive immunity.

Conditions treated with IVIg include primary immunodeficiency disorders, autoimmune diseases like Guillain-Barré syndrome and myasthenia gravis, and certain inflammatory conditions. The production and administration of IVIg are highly regulated to ensure safety and efficacy.