fosfimyas

Fosfomycin is an antibiotic that belongs to the phosphonic acid class. It is a broad-spectrum antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria. Fosfomycin works by inhibiting the synthesis of bacterial cell walls, a crucial process for bacterial survival. Specifically, it targets the enzyme MurA, which is involved in the early stages of peptidoglycan synthesis. This mechanism of action makes it distinct from many other antibiotics, contributing to its utility in treating infections caused by bacteria that have developed resistance to other drugs.

Fosfomycin is typically administered orally or intravenously, depending on the severity and location of the infection. It is primarily used to treat urinary tract infections (UTIs), particularly those caused by Escherichia coli and Enterococcus faecalis, which are common culprits. Due to its efficacy and favorable safety profile, it is often considered a first-line treatment for uncomplicated UTIs. In some regions, fosfomycin is also used for other types of infections, including respiratory tract infections and bone and joint infections, although its use in these areas may be less common or reserved for specific circumstances.

The development of antibiotic resistance is a significant concern in healthcare. Fosfomycin's unique mechanism of action can help overcome resistance to other antibiotic classes. However, resistance to fosfomycin can also develop, underscoring the importance of appropriate use and stewardship. Due to potential interactions and specific dosing requirements, fosfomycin should only be used under the guidance of a healthcare professional. Its availability and approved uses can vary by country.