excitotoxicitate
Excitotoxicitate (excitotoxicity) is a pathological process in which neurons are damaged or killed due to excessive activation of glutamate receptors, particularly NMDA and AMPA receptors, leading to intracellular calcium overload.
Under pathological conditions, excessive glutamate release or impaired clearance by astrocytes increases extracellular glutamate. NMDA/AMPA receptor
It is commonly observed in ischemic stroke, traumatic brain injury, and spinal cord injury, and is implicated
Therapeutic strategies aim to limit excitotoxicity by modulating glutamate signaling, enhancing astrocytic uptake, blocking NMDA receptors,