ergocornine

Ergocornine is a naturally occurring ergot alkaloid, a type of psychoactive compound produced by certain fungi, most notably species of *Claviceps*. These fungi typically infect grains like rye, wheat, and barley, leading to ergotism in humans and livestock who consume contaminated grain. Ergocornine belongs to the ergoline alkaloid group, characterized by its ergoline ring system. Chemically, it is a complex organic molecule derived from lysergic acid.

Pharmacologically, ergocornine is known for its antagonistic effects on dopamine receptors, particularly D2 receptors, and also exhibits activity at serotonin and adrenergic receptors. Historically, ergot alkaloids, including ergocornine, have been investigated for various medicinal applications, such as in the treatment of migraine headaches and postpartum hemorrhage due to their vasoconstrictive properties. However, the use of pure ergocornine in modern medicine is limited due to its complex pharmacology and potential for side effects. Research continues to explore the therapeutic potential and mechanisms of action of ergocornine and related ergot alkaloids.