eIF3I

eIF3I, also known as eukaryotic translation initiation factor 3 subunit I, is a protein component of the human eukaryotic translation initiation factor 3 (eIF3) complex. The eIF3 complex is a large, multi-subunit assembly that plays a crucial role in initiating protein synthesis, a fundamental process in all eukaryotic cells. Specifically, eIF3I is one of the subunits that contribute to the overall structure and function of the eIF3 complex. The eIF3 complex is involved in several steps of translation initiation, including binding to the 40S ribosomal subunit, recruiting the initiator tRNA, and facilitating the assembly of the 80S ribosome. The precise function of each individual subunit within eIF3, including eIF3I, is still an active area of research. However, it is understood that the coordinated action of all eIF3 subunits is essential for efficient and regulated translation initiation. Dysregulation of translation initiation, and by extension, components like eIF3I, has been implicated in various cellular processes and diseases, including cancer. Further investigation into the specific roles of eIF3I and its interactions within the eIF3 complex and with other cellular machinery is ongoing to fully elucidate its contribution to cellular function and disease pathogenesis.