e00

E00 is an ICD-10 code used to classify congenital iodine-deficiency syndrome, a condition that results from insufficient iodine intake during fetal development. Iodine is essential for thyroid hormone production; deficiency during pregnancy can lead to a spectrum of thyroid dysfunction in the newborn, ranging from goiter to cretinism and hypothyroidism, with potential impact on growth and neurodevelopment. In ICD-10, E00 falls within the chapter on endocrine, nutritional and metabolic diseases, with subcategories such as E00.0, E00.1, etc., that specify particular clinical manifestations such as congenital goiter, cretinism, or hypothyroidism.

Clinical features vary by severity but often include enlarged thyroid gland at birth, slowed growth, and developmental delays. Early neonatal screening and thyroid function testing can facilitate diagnosis. Treatment is oriented toward correcting thyroid hormone deficiency, using appropriate levothyroxine therapy when indicated, and addressing iodine deficiency in the mother during pregnancy. In regions with endemic iodine deficiency, public health measures to increase iodine intake—notably iodized salt—are crucial for prevention.

E00 is primarily of interest in medical coding and epidemiology, used for charting, research, and health statistics. Awareness of iodine status in populations remains an important public health issue to prevent congenital thyroid disorders.