direabsorpsi

Direabsorpsi is a term used in physiology and pharmacology to describe the direct uptake of substances into the circulatory system from a site of contact, bypassing or minimizing metabolic processing. The term can refer to two related contexts: reabsorption in excretory systems, particularly the kidneys, and routes of drug administration that deliver substances directly to systemic circulation, avoiding extensive first-pass liver metabolism.

In renal physiology, direabsorpsi describes how filtered substances are reclaimed into the blood. The proximal tubule reabsorbs the majority of filtered glucose, amino acids, ions, and water; selective transporters and water channels regulate the amount recovered, and hormonal signals adjust reabsorption according to the body’s needs. The process is essential for fluid and electrolyte balance and for conserving nutrients.

In pharmacology and medicine, direabsorpsi also refers to routes of administration designed for rapid systemic exposure, such as sublingual, buccal, intranasal, transdermal, inhalation, or rectal routes. These routes strive to minimize first-pass hepatic metabolism and provide quicker onset of action. The efficiency depends on drug properties (lipophilicity, molecular size), formulation, and local physiology.

Overall, direabsorpsi describes a broad concept of direct transfer of substances into the bloodstream, either through renal reabsorption or site-specific administration, with important implications for physiology, pharmacokinetics, and clinical therapy.